Why PGX Testing May Be Required

Healthcare is a complex field that’s constantly evolving. Today, the field has seen significant advancements that help deliver more practical solutions. While seeking healthcare services, your doctor may recommend PGx testing. While the test may not seem directly linked to your ailment, it is essential to help fast-track your treatment. PGx testing examines how genetic makeup impacts your body’s interaction with certain medications. Pharmacogenomics (PGx) testing combines the study of drugs (pharmacology) and genes and their functions (genomics). The testing considers genes associated with how your body processes and responds to medication. This facilitates the development of personalized medicine. Among the top instances your healthcare provider may request or recommend PGx testing includes:

Mitigate side effect chances

Have you ever had a significant side effect from certain medications? Certain drugs can cause unpleasant reactions like:

Dry mouth



Nausea or a rash

Others can lead to severe side effects. Medication aimed to help you recover could lead to a life-threatening instance, permanent damage or disability, hospitalization, or even death.

Side effects can appear:

When you start taking a new drug or dietary supplement

Shortly after you stop taking medication, you’ve been on for some time

After increasing or decreasing the dosage

If you notice side effects, talk to your healthcare provider whether you are taking prescription, controlled, or over-the-counter drugs. The professional can help alleviate or eliminate the side effects by adjusting the dosage or switching to a different medication. They could also recommend certain changes like lifestyle modification, taking the drugs with food, dietary changes, or taking the medicine with another.

PGx testing is the most practical approach if the side effects are adverse. This helps ensure that the professional narrows down the most likely drug causing the side effects. Once established, they’ll be better positioned to prescribe medication less likely to interact with your genes adversely and facilitate better progress.

Proper dosage

Have you taken a certain medication but felt little or no effect? The drug might not be the problem but rather the dosage. When developing the dosage, healthcare providers consider factors like:




Administration mode and time

Medical conditions

Certain environmental factors

Such factors are more generalized since they aren’t considered with your body’s response in mind.

If the dosage prescribed is not delivering results, the doctor may adjust following certain more specific considerations like the condition, how it is progressing, and potential side effects. PGx testing provides a more accurate dosage guideline. The results provide a detailed view of your genetics and how they affect medication interaction. This is critical when managing conditions that may require taking multiple drugs.

Following the results helps ensure that the doctors arrive at an ideal medication dose with a higher chance of working as intended, accounting for interaction with your body, other medications, and factors like your surroundings. This helps ensure that you take the right dosage without being exposed to an increased risk of adverse side effects, such as if you take an overdose. Sometimes, the doctor may deem it necessary not to change the dosage but rather switch to a different medication with a higher success chance.

To establish if a different medication is needed

Have you stopped taking a certain drug after a while since it doesn’t seem to work anymore? Your body’s interaction with drugs and other elements can cause changes impacting their usefulness. This is seen in more pain management cases where the body may even get accustomed to certain brands that you experience no notable pain alleviation even at high dosages. For instance, opioids deliver pain relief by blocking pain signals. However, your body may increase the number of pain receptors over time, which allows the pain signal to get through, meaning you may not get as much relief.

PGx testing can help understand if there are any gene mutations affecting drug interactions. This could be a response to the drug, which could even do some harm, such as leading to an autoimmune disorder. Drug-induced lupus is among the common autoimmune disorders associated with medications used in high blood pressure and heart rhythms treatments. If the test shows such potential, the doctor can find an alternative that’s less likely to affect your body while striving to address an illness.

Optimize outcomes

Treating certain medical conditions requires an intricate strategy. This includes routine tests and observation to monitor the progress. Continuous monitoring, mainly seen in chronic condition management, helps establish if the treatment is working as intended. This includes considering the drugs used, establishing if switching is ideal, or dosage adjustment may be necessary. The monitoring helps mitigate adverse drug reactions chances or sticking to an ineffective treatment that could expose you to considerable complications.

PGx testing provides valuable details critical in treating and managing concerns like cardiovascular disease, cancer, and psychiatric disorders, to name a few. The healthcare provider uses the results to optimize the treatment plan based on a patient’s genetic profile. This enhances the chances of desirable outcomes while ensuring patient safety is prioritized.

Genes determine many aspects, like your blood type and eye color. They also impact your bodily processes and response to medication and other elements. Genes are inherited from your parents, which is why certain conditions tend to run in families. You can’t modify your genes, which makes it essential that your healthcare understands them and how they impact your overall health and drug interactions. This way, you can avoid serious side effects when being treated for certain diseases. PGx testing also helps ensure that the most viable treatment is implemented, which can mitigate the risk of complications due to poorly managed problems like high blood pressure.

PGx testing might seem unnecessary, especially if you are concerned about its financial implications if it is unclear whether your insurance will cover the cost. Nonetheless, as you endeavor to ensure you receive the best healthcare services, it is more than a worthy measure. This is more so considering your family and medical history, especially when dealing with serious or chronic conditions.

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